---
title: "A student studies the phosphorylation of glucose in a buffered metabolic system. In the simplified equations, (text{G}) represents glucose, (text{G6P}) represents glucose-6-phosphate, and (text{P}_{i}) represents inorganic phosphate. Charge-balancing proton transfers with the buffer are omitted.  | Process | Reaction | (Delta G^circ) | |—|—|—| | Glucose phosphorylation | (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}) | (+14text{ kJ/mol}) | | ATP hydrolysis | (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}) | (-30text{ kJ/mol}) |  Which proposed sequence correctly couples ATP hydrolysis to glucose phosphorylation and gives a thermodynamically favorable net process?"
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url: "https://nerd-notes.com/ubq/119506/"
date_modified: "2026-08-19T12:40:52+00:00"
---

# A student studies the phosphorylation of glucose in a buffered metabolic system. In the simplified equations, (text{G}) represents glucose, (text{G6P}) represents glucose-6-phosphate, and (text{P}_{i}) represents inorganic phosphate. Charge-balancing proton transfers with the buffer are omitted.

| Process | Reaction | (Delta G^circ) |
|—|—|—|
| Glucose phosphorylation | (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}) | (+14text{ kJ/mol}) |
| ATP hydrolysis | (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}) | (-30text{ kJ/mol}) |

Which proposed sequence correctly couples ATP hydrolysis to glucose phosphorylation and gives a thermodynamically favorable net process?

A student studies the phosphorylation of glucose in a buffered metabolic system. In the simplified equations, (text{G}) represents glucose, (text{G6P}) represents glucose-6-phosphate, and (text{P}_{i}) represents inorganic phosphate. Charge-balancing proton transfers with the buffer are omitted.

| Process | Reaction | (Delta G^circ) |
|---|---|---|
| Glucose phosphorylation | (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}) | (+14text{ kJ/mol}) |
| ATP hydrolysis | (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}) | (-30text{ kJ/mol}) |

Which proposed sequence correctly couples ATP hydrolysis to glucose phosphorylation and gives a thermodynamically favorable net process?

- **A.** Sequence: (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}); (text{G6P(aq)}+text{H}_2text{O(l)}rightarrowtext{G(aq)}+text{P}_{i}text{(aq)}). Net (Delta G^circ=-44text{ kJ/mol}).
- **B.** Sequence: (text{ADP(aq)}+text{P}_{i}text{(aq)}rightarrowtext{ATP(aq)}+text{H}_2text{O(l)}); (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}). Net (Delta G^circ=+44text{ kJ/mol}).
- **C.** Sequence: (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}); (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}). Net: (text{ATP(aq)}+text{G(aq)}rightarrowtext{ADP(aq)}+text{G6P(aq)}), (Delta G^circ=+16text{ kJ/mol}).
- **D.** Sequence: (text{ATP(aq)}+text{H}_2text{O(l)}rightarrowtext{ADP(aq)}+text{P}_{i}text{(aq)}); (text{G(aq)}+text{P}_{i}text{(aq)}rightarrowtext{G6P(aq)}+text{H}_2text{O(l)}). Net: (text{ATP(aq)}+text{G(aq)}rightarrowtext{ADP(aq)}+text{G6P(aq)}), (Delta G^circ=-16text{ kJ/mol}).

*The answer key and step-by-step explanation are available to logged-in users at https://nerd-notes.com/ubq/119506/*