AP Chemistry
9.7 Coupled Reactions
9.3 Gibbs Free Energy and Thermodynamic Favorability
A student studies the phosphorylation of glucose in a buffered metabolic system. In the simplified equations, \(\text{G}\) represents glucose, \(\text{G6P}\) represents glucose-6-phosphate, and \(\text{P}_{i}\) represents inorganic phosphate. Charge-balancing proton transfers with the buffer are omitted.
Which proposed sequence correctly couples ATP hydrolysis to glucose phosphorylation and gives a thermodynamically favorable net process?
| Process | Reaction | \(\Delta G^\circ\) |
|---|---|---|
| Glucose phosphorylation | \(\text{G(aq)} + \text{P}_{i}\text{(aq)} \rightarrow \text{G6P(aq)} + \text{H}_2\text{O(l)}\) | \(+14 \, \text{kJ/mol}\) |
| ATP hydrolysis | \(\text{ATP(aq)} + \text{H}_2\text{O(l)} \rightarrow \text{ADP(aq)} + \text{P}_{i}\text{(aq)}\) | \(-30 \, \text{kJ/mol}\) |
Which proposed sequence correctly couples ATP hydrolysis to glucose phosphorylation and gives a thermodynamically favorable net process?
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